Reference - Detail
RRC ID | 28448 |
---|---|
Author | Inuzuka H, Miyatani S, Takeichi M. |
Title | R-cadherin: a novel Ca(2+)-dependent cell-cell adhesion molecule expressed in the retina. |
Journal | Neuron |
Abstract |
cDNAs encoding a novel member of the cadherin cell adhesion receptor family were cloned. This cadherin is expressed in the retina of the chicken and is termed R-cadherin. It is similar to other cadherins in its primary structure, but most resembles N-cadherin, showing 74% amino acid identity. Cells expressing R-cadherin can adhere to those expressing N-cadherin when mixed, but they form homotypic clusters within their chimeric aggregates. In the development of the neural retina, R-cadherin begins to be expressed around embryonic day 8 in both neuronal and glial cells, and this expression continues up to the hatching stage. The pattern of the expression of R-cadherin was different from that of N-cadherin, suggesting distinctive roles in retinal morphogenesis. |
Volume | 7(1) |
Pages | 69-79 |
Published | 1991-7-1 |
DOI | 10.1016/0896-6273(91)90075-b |
PII | 0896-6273(91)90075-B |
PMID | 1712604 |
MeSH | Amino Acid Sequence Animals Cadherins / genetics Cadherins / metabolism Cadherins / physiology* Cell Adhesion Molecules / metabolism Cell Adhesion Molecules / physiology* Chick Embryo DNA / metabolism Fluorescent Antibody Technique Molecular Sequence Data Retina / metabolism* Staining and Labeling |
IF | 14.415 |
Times Cited | 203 |
WOS Category | NEUROSCIENCES |
Resource | |
DNA material | Chicken R-cadherin full length cDNA (RDB01188). |