RRC ID 28690
著者 Kono H, Tamura M, Osada N, Suzuki H, Abe K, Moriwaki K, Ohta K, Shiroishi T.
タイトル Prdm9 polymorphism unveils mouse evolutionary tracks.
ジャーナル DNA Res
Abstract PR/SET domain containing 9 (Prdm9) mediates histone modifications such as H3K4me3 and marks hotspots of meiotic recombination. In many mammalian species, the Prdm9 gene is highly polymorphic. Prdm9 polymorphism is assumed to play two critical roles in evolution: to diversify the spectrum of meiotic recombination hotspots and to cause male hybrid sterility, leading to reproductive isolation and speciation. Nevertheless, information about Prdm9 sequences in natural populations is very limited. In this study, we conducted a comprehensive population survey on Prdm9 polymorphism in the house mouse, Mus musculus. Overall M. musculus Prdm9 displays an extraordinarily high level of polymorphism, particularly in regions encoding zinc finger repeats, which recognize recombination hotspots. Prdm9 alleles specific to various M. musculus subspecies dominate in subspecies territories. Moreover, introgression into other subspecies territories was found for highly divergent Prdm9 alleles associated with t-haplotype. The results of our phylogeographical analysis suggest that the requirement for hotspot diversity depends on geographical range and time span in mouse evolution, and that Prdm9 polymorphism has not been maintained by a simple balanced selection in the population of each subspecies.
巻・号 21(3)
ページ 315-26
公開日 2014-6-1
DOI 10.1093/dnares/dst059
PII dst059
PMID 24449848
PMC PMC4060951
MeSH Amino Acid Sequence Animals Chromosomes, Mammalian Evolution, Molecular* Haplotypes Histone-Lysine N-Methyltransferase / genetics* Mice / genetics* Molecular Sequence Data Phylogeny Phylogeography Polymorphism, Genetic Species Specificity Zinc Fingers
IF 4.009
引用数 31
WOS 分野 GENETICS & HEREDITY
リソース情報
実験動物マウス RBRC00208