RRC ID 2876
著者 Sekimizu K, Tagawa M, Takeda H.
タイトル Defective fin regeneration in medaka fish (Oryzias latipes) with hypothyroidism.
ジャーナル Zoolog Sci
Abstract Wild-type medaka are known to have remarkable capabilities of fin, or epimorphic, regeneration. However, a hypothyroid mutant, kamaitachi (kmi), frequently suffers from injury in fins, suggesting an important role of thyroid hormone in fin regeneration. This led us to examine the relationship between thyroid hormone and fin regeneration using medaka as a model. For this, we first set up a medaka experimental system in which the rate of regeneration was statistically analyzed after caudal fin amputation under normal and hypothyroid conditions. As expected, the regeneration of amputated caudal fins was delayed in hypothyroid kmi -/- mutants. We then examined wild-type medaka with thiourea-induced hypothyroidism to evaluate the requirement of thyroid hormone during epimorphic fin regeneration. The results demonstrate that the growth rate of regenerates was much reduced in severely hypothyroid medaka throughout the regeneration period. This reduction in regenerative rate was recovered by exogenous administration of L-thyroxine. The present study is thus the first to report the direct involvement of thyroid hormone in teleost fin regeneration, and provides a basic framework for future molecular and genetic analyses.
巻・号 24(7)
ページ 693-9
公開日 2007-7-1
DOI 10.2108/zsj.24.693
PII 0289-0003-24-7-693
PMID 17824777
MeSH Animals Antibodies / metabolism Antithyroid Agents / toxicity Extremities / physiology* Female Fish Diseases / chemically induced Fish Diseases / genetics Fish Diseases / physiopathology* Hypothyroidism / chemically induced Hypothyroidism / physiopathology Hypothyroidism / veterinary* Male Models, Animal Oryzias / physiology* Radioimmunoassay / veterinary Regeneration / drug effects Regeneration / physiology* Thiourea / toxicity Thyroid Hormones / physiology Thyroxine / toxicity Time Factors
IF 0.843
引用数 7
WOS 分野 ZOOLOGY
リソース情報
メダカ folicless (MT146) orange-red variety