Reference - Detail
| RRC ID | 28844 |
|---|---|
| Author | Fitzsimons HL, Schwartz S, Given FM, Scott MJ. |
| Title | The histone deacetylase HDAC4 regulates long-term memory in Drosophila. |
| Journal | PLoS One |
| Abstract |
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive function. Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila. We show that overexpression of HDAC4 in the adult mushroom body, an important structure for memory formation, resulted in a specific impairment in long-term courtship memory, but had no affect on short-term memory. Overexpression of an HDAC4 catalytic mutant also abolished LTM, suggesting a mode of action independent of catalytic activity. We found that overexpression of HDAC4 resulted in a redistribution of the transcription factor MEF2 from a relatively uniform distribution through the nucleus into punctate nuclear bodies, where it colocalized with HDAC4. As MEF2 has also been implicated in regulation of long-term memory, these data suggest that the repressive effects of HDAC4 on long-term memory may be through interaction with MEF2. In the same genetic background, we also found that RNAi-mediated knockdown of HDAC4 impairs long-term memory, therefore we demonstrate that HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation. |
| Volume | 8(12) |
| Pages | e83903 |
| Published | 2013-12-9 |
| DOI | 10.1371/journal.pone.0083903 |
| PII | PONE-D-13-35023 |
| PMID | 24349558 |
| PMC | PMC3857321 |
| MeSH | Animals Drosophila Proteins / biosynthesis* Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster Gene Expression Regulation, Enzymologic / physiology* Gene Knockdown Techniques Histone Deacetylases / biosynthesis* Histone Deacetylases / genetics Memory, Long-Term / physiology* Mushroom Bodies / cytology Mushroom Bodies / enzymology* Myogenic Regulatory Factors / genetics Myogenic Regulatory Factors / metabolism |
| IF | 2.74 |
| Times Cited | 40 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#104052 DGRC#104540 |