論文 - 詳細
| RRC ID | 28904 |
|---|---|
| 著者 | Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, Liu F, Zhang L, Zhao Y. |
| タイトル | Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. |
| ジャーナル | J Cell Biol |
| Abstract |
The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (Ci(R)/Gli(R)) and activator (Ci(A)/Gli(A)) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which Ci(R)/Gli(R) properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor. |
| 巻・号 | 203(4) |
| ページ | 575-83 |
| 公開日 | 2013-11-25 |
| DOI | 10.1083/jcb.201306012 |
| PII | jcb.201306012 |
| PMID | 24385484 |
| PMC | PMC3840934 |
| MeSH | Acetylation Animals Binding Sites Co-Repressor Proteins / metabolism DNA-Binding Proteins / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism Evolution, Molecular Genetic Loci / genetics Hedgehog Proteins / metabolism* Histone Deacetylase 1 / metabolism* Histones / metabolism Humans Intracellular Signaling Peptides and Proteins Protein Binding Signal Transduction* Transcription Factors / metabolism* Zebrafish / metabolism Zebrafish Proteins / metabolism* |
| IF | 8.811 |
| 引用数 | 19 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 2125R-1 |