論文 - 詳細
| RRC ID | 29034 |
|---|---|
| 著者 | Okuwa T, Katayama T, Takano A, Kodaira K, Yasukawa H. |
| タイトル | Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum. |
| ジャーナル | Dev Growth Differ |
| Abstract |
Countin, a cell-counting factor in Dictyostelium discoideum, is considered to limit the maximum size of the multicellular structure, because a countin null strain forms a huge fruiting body compared to that of the wild-type. A novel gene, countin2, that is highly homologous to countin (40% identity in amino acid sequence) was identified in the D. discoideum genome. The countin2 null strain formed a 1.7-fold higher number of the aggregates, resulting in smaller fruiting bodies compared with those of wild-type cells. Thus, the Countin2 protein is thought to limit the minimum size of the multicellular structure. The size and number of aggregates formed by a mixture of countin null and countin2 null strains were the same as those of the wild-type. These findings demonstrate that a combination of Countin and Countin2 proteins determines the appropriate size of the multicellular structure of D. discoideum. |
| 巻・号 | 43(6) |
| ページ | 735-44 |
| 公開日 | 2001-12-1 |
| DOI | 10.1046/j.1440-169x.2001.00615.x |
| PII | 615 |
| PMID | 11737154 |
| MeSH | Amino Acid Sequence Animals Base Sequence DNA, Complementary Dictyostelium / cytology* Dictyostelium / genetics Molecular Sequence Data Phenotype Protozoan Proteins / chemistry Protozoan Proteins / genetics Protozoan Proteins / physiology* Sequence Homology, Amino Acid |
| IF | 1.723 |
| 引用数 | 14 |
| WOS 分野 | CELL BIOLOGY DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 細胞性粘菌 | S00325 |