| RRC ID |
29034
|
| 著者 |
Okuwa T, Katayama T, Takano A, Kodaira K, Yasukawa H.
|
| タイトル |
Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum.
|
| ジャーナル |
Dev Growth Differ
|
| Abstract |
Countin, a cell-counting factor in Dictyostelium discoideum, is considered to limit the maximum size of the multicellular structure, because a countin null strain forms a huge fruiting body compared to that of the wild-type. A novel gene, countin2, that is highly homologous to countin (40% identity in amino acid sequence) was identified in the D. discoideum genome. The countin2 null strain formed a 1.7-fold higher number of the aggregates, resulting in smaller fruiting bodies compared with those of wild-type cells. Thus, the Countin2 protein is thought to limit the minimum size of the multicellular structure. The size and number of aggregates formed by a mixture of countin null and countin2 null strains were the same as those of the wild-type. These findings demonstrate that a combination of Countin and Countin2 proteins determines the appropriate size of the multicellular structure of D. discoideum.
|
| 巻・号 |
43(6)
|
| ページ |
735-44
|
| 公開日 |
2001-12-1
|
| DOI |
10.1046/j.1440-169x.2001.00615.x
|
| PII |
615
|
| PMID |
11737154
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary
Dictyostelium / cytology*
Dictyostelium / genetics
Molecular Sequence Data
Phenotype
Protozoan Proteins / chemistry
Protozoan Proteins / genetics
Protozoan Proteins / physiology*
Sequence Homology, Amino Acid
|
| IF |
1.723
|
| 引用数 |
14
|
|
WOS 分野
|
CELL BIOLOGY
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| 細胞性粘菌 |
S00325 |
