論文 - 詳細
| RRC ID | 29077 |
|---|---|
| 著者 | Pollitt AY, Blagg SL, Ibarra N, Insall RH. |
| タイトル | Cell motility and SCAR localisation in axenically growing Dictyostelium cells. |
| ジャーナル | Eur J Cell Biol |
| Abstract |
Dictyostelium is a popular experimental organism, in particular for studies of actin dynamics, cell motility and chemotaxis. We find that the motility of axenic cells is unexpectedly different from other strains during growth. In particular, vegetative AX3 cells do not show detectable localisation of SCAR and its regulatory complex to actin-rich protrusions such as filopodia and pseudopodia. Similarly, a range of different mutations, in particular knockouts of members of the SCAR complex and Ras proteins, cause different phenotypes during vegetative growth in different parental strains. Development reverses this unusual behaviour; aggregation-competent AX3 cells localise SCAR in the same way as cells of other strains and species. Studies on cell motility using vegetative cells should therefore be interpreted with caution. |
| 巻・号 | 85(9-10) |
| ページ | 1091-8 |
| 公開日 | 2006-9-1 |
| DOI | 10.1016/j.ejcb.2006.05.014 |
| PII | S0171-9335(06)00107-5 |
| PMID | 16822579 |
| MeSH | Animals Behavior, Animal / physiology Cell Movement / physiology* Dictyostelium / cytology Dictyostelium / physiology* Genotype Germ-Free Life Phenotype Protozoan Proteins / metabolism* ras Proteins / genetics ras Proteins / metabolism |
| IF | 3.025 |
| 引用数 | 17 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 細胞性粘菌 | S00181 |