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Species Resource Title
Drosophila DGRC#202812 Generation of Mutants from the 57B Region of Drosophila melanogaster.
Human and Animal Cells HCT116(RCB2979) , Colon-26(RCB2657) Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains.
C.elegans tm810 Discovery of nonautonomous modulators of activated Ras.
Drosophila EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis.
Human and Animal Cells CW-2(RCB0778) Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling.
Human and Animal Cells HeLa(RCB0007) Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling.
Human and Animal Cells MMAc·SF(RCB1200) Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Human and Animal Cells COLO205(RCB2127) , JHCOLOYI(RCB1706) , PMF-ko14(RCB1426) EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer.
Human and Animal Cells HKBML(RCB0820) Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells.
Drosophila 8486R-3 , 7563R-3 Dissemination of RasV12-transformed cells requires the mechanosensitive channel Piezo.
C.elegans tm2760 , tm5205 , tm2255 , tm6137 Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals.
Human and Animal Cells Ba/F3(RCB0805) RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia.
Drosophila Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability.
Human and Animal Cells HuH-7 HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib.
Cellular slime molds Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells.
C.elegans tm748 Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory.
Human and Animal Cells Ca9-22(RCB1976) The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.
Human and Animal Cells Hep G2(RCB1886) δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.
DNA material CSII-CMV-RfA (RDB04386) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.
C.elegans tm853 Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.