RRC ID 29100
Author Hirose S, Benabentos R, Ho HI, Kuspa A, Shaulsky G.
Title Self-recognition in social amoebae is mediated by allelic pairs of tiger genes.
Journal Science
Abstract Free-living cells of the social amoebae Dictyostelium discoideum can aggregate and develop into multicellular fruiting bodies in which many die altruistically as they become stalk cells that support the surviving spores. Dictyostelium cells exhibit kin discrimination--a potential defense against cheaters, which sporulate without contributing to the stalk. Kin discrimination depends on strain relatedness, and the polymorphic genes tgrB1 and tgrC1 are potential components of that mechanism. Here, we demonstrate a direct role for these genes in kin discrimination. We show that a matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognition, which is mediated by differential cell-cell adhesion. We propose that TgrB1 and TgrC1 proteins mediate this adhesion through direct binding. This system is a genetically tractable ancient model of eukaryotic self-recognition.
Volume 333(6041)
Pages 467-70
Published 2011-7-22
DOI 10.1126/science.1203903
PII science.1203903
PMID 21700835
PMC PMC3142563
MeSH Alleles Amino Acid Sequence Cell Adhesion* Cell Aggregation Dictyostelium / genetics* Dictyostelium / physiology* Gene Deletion Genes, Protozoan* Molecular Sequence Data Protein Binding Protozoan Proteins / metabolism* Spores, Protozoan / physiology
IF 41.846
Times Cited 79
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