論文 - 詳細
| RRC ID | 29100 |
|---|---|
| 著者 | Hirose S, Benabentos R, Ho HI, Kuspa A, Shaulsky G. |
| タイトル | Self-recognition in social amoebae is mediated by allelic pairs of tiger genes. |
| ジャーナル | Science |
| Abstract |
Free-living cells of the social amoebae Dictyostelium discoideum can aggregate and develop into multicellular fruiting bodies in which many die altruistically as they become stalk cells that support the surviving spores. Dictyostelium cells exhibit kin discrimination--a potential defense against cheaters, which sporulate without contributing to the stalk. Kin discrimination depends on strain relatedness, and the polymorphic genes tgrB1 and tgrC1 are potential components of that mechanism. Here, we demonstrate a direct role for these genes in kin discrimination. We show that a matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognition, which is mediated by differential cell-cell adhesion. We propose that TgrB1 and TgrC1 proteins mediate this adhesion through direct binding. This system is a genetically tractable ancient model of eukaryotic self-recognition. |
| 巻・号 | 333(6041) |
| ページ | 467-70 |
| 公開日 | 2011-7-22 |
| DOI | 10.1126/science.1203903 |
| PII | science.1203903 |
| PMID | 21700835 |
| PMC | PMC3142563 |
| MeSH | Alleles Amino Acid Sequence Cell Adhesion* Cell Aggregation Dictyostelium / genetics* Dictyostelium / physiology* Gene Deletion Genes, Protozoan* Molecular Sequence Data Protein Binding Protozoan Proteins / metabolism* Spores, Protozoan / physiology |
| IF | 41.846 |
| 引用数 | 79 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 細胞性粘菌 | S00483 |