論文 - 詳細
| RRC ID | 29153 |
|---|---|
| 著者 | Yoshida M, Kaneko M, Kurachi H, Osawa M. |
| タイトル | Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: a gene family including the gene for prolactin-inducible protein. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
We cloned two new paralogous genes that encode proteins homologous to seminal vesicle autoantigen (SVA) in rodents. The open reading frame of one mouse gene encodes a polypeptide consisting of 151 amino acid residues which has 43% identity to SVA. RT-PCR analysis showed selective expression in the colon, and thus the protein was tentatively named "SVA-like protein in the colon (SLP-C)". The other mouse gene has an open reading frame encoding 144 amino acid residues with 46 and 65% identity to SVA and SLP-C, respectively. Expression of this gene was detected in the mammary, submaxillary, parotid, and lacrimal glands, and this protein was named "SLP in the mammary gland (SLP-M)". Orthologs of both genes were also found in rats. The three homologous genes coding for SVA, SLP-C, and SLP-M may have been generated by gene duplication with divergence of tissue expression in the course of evolution. They comprise a unique structurally-related gene family. Moreover, these genes share significant sequence homology with that of another secretory glycoprotein, prolactin-inducible protein. |
| 巻・号 | 281(1) |
| ページ | 94-100 |
| 公開日 | 2001-2-16 |
| DOI | 10.1006/bbrc.2001.4311 |
| PII | S0006-291X(01)94311-6 |
| PMID | 11178965 |
| MeSH | Amino Acid Sequence Amino Acids / chemistry Animals Apoptosis Aspartic Acid Endopeptidases Autoantigens / chemistry Autoantigens / genetics* Base Sequence Carrier Proteins / genetics* Cloning, Molecular Colon / metabolism DNA, Complementary / metabolism Female Glycoproteins / chemistry Glycoproteins / genetics* Lacrimal Apparatus / metabolism Liver / metabolism Mammary Glands, Animal / metabolism Mice Multigene Family* Open Reading Frames Parotid Gland / metabolism Peptides / chemistry Phylogeny Rats Reverse Transcriptase Polymerase Chain Reaction Seminal Vesicle Secretory Proteins* Sequence Analysis, DNA Sequence Homology, Amino Acid Submandibular Gland / metabolism Tissue Distribution |
| IF | 2.985 |
| 引用数 | 9 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | p123T-mSLP-C (RDB02970) p123T-mSLP-M (RDB02971) p123T-rSLP-C (RDB02972) p123T-rSLP-M (RDB02973) |