論文 - 詳細
| RRC ID | 29203 |
|---|---|
| 著者 | Nakashima N, Tanaka K, Sturm S, Okayama H. |
| タイトル | Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10. |
| ジャーナル | EMBO J |
| Abstract |
In the yeast cell cycle 'start' requires sets of the Cdc10/ SWI family of transcriptional factors which activate the MCB cis elements contained in genes essential for S phase progression. Fission yeast possess two such overlapping systems, Res1-Cdc10 and Res2-Cdc10, both of which act to start the mitotic and meiotic cycles. We have recently isolated rep2+ as a multicopy suppressor of a temperature-sensitive cdc10 mutant which encodes a zinc finger protein. Here we show that the Rep2 zinc finger protein is an essential component of the active Res2-Cdc10 transcriptional regulator complex and likely to play a role in the control of cell cycle 'start'. Our data suggest that Rep2 is a transcriptional activator subunit which interacts with the MCB binding subunit complex formed by Res2 and Cdc10. |
| 巻・号 | 14(19) |
| ページ | 4794-802 |
| 公開日 | 1995-10-2 |
| DOI | 10.1002/j.1460-2075.1995.tb00161.x |
| PMID | 7588609 |
| PMC | PMC394577 |
| MeSH | Amino Acid Sequence Base Sequence Cell Cycle Proteins / metabolism* Cell Cycle Proteins / physiology Cloning, Molecular DNA / metabolism DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism DNA-Binding Proteins / physiology* Fungal Proteins / genetics Fungal Proteins / metabolism* Fungal Proteins / physiology G1 Phase / genetics* Genes, Fungal / genetics Genes, Regulator / genetics Meiosis / genetics Mitosis / genetics Models, Genetic Molecular Sequence Data Nitrogen / physiology Schizosaccharomyces / genetics Schizosaccharomyces / growth & development Schizosaccharomyces pombe Proteins* Sequence Analysis, DNA Sequence Homology, Amino Acid Suppression, Genetic Trans-Activators / chemistry Trans-Activators / genetics Trans-Activators / metabolism Trans-Activators / physiology* Transcription Factors Zinc Fingers / genetics |
| IF | 9.889 |
| 引用数 | 55 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 遺伝子材料 | rep2^+ (RDB01609) |