Reference - Detail
| RRC ID | 29273 |
|---|---|
| Author | Zhang W, Fortman JL, Carlson JC, Yan J, Liu Y, Bai F, Guan W, Jia J, Matainaho T, Sherman DH, Li S. |
| Title | Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii. |
| Journal | Chembiochem |
| Abstract |
New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering. |
| Volume | 14(3) |
| Pages | 301-6 |
| Published | 2013-2-11 |
| DOI | 10.1002/cbic.201200743 |
| PMID | 23362147 |
| PMC | PMC3771327 |
| MeSH | Antifungal Agents / chemistry Antifungal Agents / metabolism Gene Library Macrolides / chemistry Macrolides / metabolism* Multigene Family Polyketide Synthases / genetics Polyketide Synthases / metabolism Streptomyces / genetics* |
| IF | 2.576 |
| Times Cited | 20 |
| WOS Category | CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| General Microbes | JCM 14114 |