論文 - 詳細
RRC ID | 29273 |
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著者 | Zhang W, Fortman JL, Carlson JC, Yan J, Liu Y, Bai F, Guan W, Jia J, Matainaho T, Sherman DH, Li S. |
タイトル | Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii. |
ジャーナル | Chembiochem |
Abstract |
New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering. |
巻・号 | 14(3) |
ページ | 301-6 |
公開日 | 2013-2-11 |
DOI | 10.1002/cbic.201200743 |
PMID | 23362147 |
PMC | PMC3771327 |
MeSH | Antifungal Agents / chemistry Antifungal Agents / metabolism Gene Library Macrolides / chemistry Macrolides / metabolism* Multigene Family Polyketide Synthases / genetics Polyketide Synthases / metabolism Streptomyces / genetics* |
IF | 2.576 |
引用数 | 20 |
WOS 分野 | CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
一般微生物 | JCM 14114 |