RRC ID 29273
著者 Zhang W, Fortman JL, Carlson JC, Yan J, Liu Y, Bai F, Guan W, Jia J, Matainaho T, Sherman DH, Li S.
タイトル Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.
ジャーナル Chembiochem
Abstract New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.
巻・号 14(3)
ページ 301-6
公開日 2013-2-11
DOI 10.1002/cbic.201200743
PMID 23362147
PMC PMC3771327
MeSH Antifungal Agents / chemistry Antifungal Agents / metabolism Gene Library Macrolides / chemistry Macrolides / metabolism* Multigene Family Polyketide Synthases / genetics Polyketide Synthases / metabolism Streptomyces / genetics*
IF 2.576
引用数 20
WOS 分野 CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 14114