Reference - Detail
| RRC ID | 29752 |
|---|---|
| Author | Horiuchi T, Maki H, Sekiguchi M. |
| Title | A new conditional lethal mutator (dnaQ49) in Escherichia coli K12. |
| Journal | Mol Gen Genet |
| Abstract |
A conditional lethal mutator, dnaQ49, was found in Escherichia coli K12. The dnaQ49 mutation caused stimulation of rifampicin-, nalidixic acid- and streptomycin-resistant mutation frequencies 100 to 2000 fold at 30 degrees C and the frequencies were further increased 50 to 100 fold at 35 degrees C or higher temperatures. Cells carrying dnaQ49 were unable to grow in salt-free L-broth at 44.5 degrees C, and DNA synthesis but not protein synthesis of the cells was suppressed under the restrictive conditions. The dnaQ gene was located at about 5 min on the E. coli linkage map and the order of the genes residing in this region was determined to be ton A-dnaE-metD-dnaQ-pro A. |
| Volume | 163(3) |
| Pages | 277-83 |
| Published | 1978-7-25 |
| DOI | 10.1007/BF00271956 |
| PMID | 355854 |
| MeSH | Chromosome Mapping Chromosomes, Bacterial DNA, Bacterial / biosynthesis* Drug Resistance, Microbial* Escherichia coli / genetics* Genes, Lethal* Hot Temperature Mutation* Nalidixic Acid / pharmacology Rifampin / pharmacology Streptomycin / pharmacology |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Prokaryotes E. coli | ME6085 |