論文 - 詳細
| RRC ID | 30224 |
|---|---|
| 著者 | Liedtke D, Erhard I, Abe K, Furutani-Seiki M, Kondoh H, Schartl M. |
| タイトル | Xmrk-induced melanoma progression is affected by Sdf1 signals through Cxcr7. |
| ジャーナル | Pigment Cell Melanoma Res |
| Abstract |
Chemokine signals mediated by Sdf1/Cxcl12 through the chemokine receptor Cxcr4 are thought to play an instructive role in tumor migration and organ-specific metastasis. We have used a small aquarium fish model to contribute to a better understanding of how the course of melanoma development is influenced by Sdf1 signals in vivo. We studied oncogene-induced skin tumor appearance and progression in the transgenic medaka (Oryzias latipes) melanoma model. Similar to humans, invasive medaka melanomas show increased levels of sdf1, cxcr4, and cxcr7 gene expression. Stable transgenic fish lines overexpressing sdf1 exclusively in pigment cells showed a reduction in melanoma appearance and progression. Remarkably, diminished levels of functional Cxcr7, but not of Cxcr4b, resulted in strongly reduced melanoma invasiveness and a repression of melanoma. Our results thereby indicate that Sdf1 signals via Cxcr7 are able to constrain melanoma growth in vivo and that these signals influence tumor outcome. |
| 巻・号 | 27(2) |
| ページ | 221-33 |
| 公開日 | 2014-3-1 |
| DOI | 10.1111/pcmr.12188 |
| PMID | 24279354 |
| MeSH | Animals Animals, Genetically Modified Cell Line, Tumor Chemokine CXCL12 / metabolism* Crosses, Genetic Disease Progression* Female Liver / metabolism Liver / pathology Male Melanoma / enzymology Melanoma / pathology* Neoplasm Invasiveness Oryzias / metabolism* Phenotype Pigmentation Receptor Protein-Tyrosine Kinases / metabolism* Receptors, CXCR / metabolism* Signal Transduction Skin Neoplasms / enzymology Skin Neoplasms / pathology* |
| IF | 3.683 |
| 引用数 | 8 |
| WOS 分野 | DERMATOLOGY ONCOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | MT385 MT443 |