| RRC ID |
30224
|
| 著者 |
Liedtke D, Erhard I, Abe K, Furutani-Seiki M, Kondoh H, Schartl M.
|
| タイトル |
Xmrk-induced melanoma progression is affected by Sdf1 signals through Cxcr7.
|
| ジャーナル |
Pigment Cell Melanoma Res
|
| Abstract |
Chemokine signals mediated by Sdf1/Cxcl12 through the chemokine receptor Cxcr4 are thought to play an instructive role in tumor migration and organ-specific metastasis. We have used a small aquarium fish model to contribute to a better understanding of how the course of melanoma development is influenced by Sdf1 signals in vivo. We studied oncogene-induced skin tumor appearance and progression in the transgenic medaka (Oryzias latipes) melanoma model. Similar to humans, invasive medaka melanomas show increased levels of sdf1, cxcr4, and cxcr7 gene expression. Stable transgenic fish lines overexpressing sdf1 exclusively in pigment cells showed a reduction in melanoma appearance and progression. Remarkably, diminished levels of functional Cxcr7, but not of Cxcr4b, resulted in strongly reduced melanoma invasiveness and a repression of melanoma. Our results thereby indicate that Sdf1 signals via Cxcr7 are able to constrain melanoma growth in vivo and that these signals influence tumor outcome.
|
| 巻・号 |
27(2)
|
| ページ |
221-33
|
| 公開日 |
2014-3-1
|
| DOI |
10.1111/pcmr.12188
|
| PMID |
24279354
|
| MeSH |
Animals
Animals, Genetically Modified
Cell Line, Tumor
Chemokine CXCL12 / metabolism*
Crosses, Genetic
Disease Progression*
Female
Liver / metabolism
Liver / pathology
Male
Melanoma / enzymology
Melanoma / pathology*
Neoplasm Invasiveness
Oryzias / metabolism*
Phenotype
Pigmentation
Receptor Protein-Tyrosine Kinases / metabolism*
Receptors, CXCR / metabolism*
Signal Transduction
Skin Neoplasms / enzymology
Skin Neoplasms / pathology*
|
| IF |
3.683
|
| 引用数 |
8
|
|
WOS 分野
|
DERMATOLOGY
ONCOLOGY
CELL BIOLOGY
|
| リソース情報 |
| メダカ |
MT385
MT443 |
