Reference - Detail
|Author||Tei H, Nihonmatsu I, Yokokura T, Ueda R, Sano Y, Okuda T, Sato K, Hirata K, Fujita SC, Yamamoto D.|
|Title||pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.|
|Journal||Proc Natl Acad Sci U S A|
Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.
|MeSH||Amino Acid Sequence Animals Base Sequence Crosses, Genetic DNA-Binding Proteins* Drosophila / genetics* Drosophila / physiology Eye Proteins / genetics* Female Genes Genetic Carrier Screening Genotype Homozygote Humans Male Molecular Sequence Data Mosaicism Photoreceptor Cells / cytology Photoreceptor Cells / physiology* Protein-Tyrosine Kinases / genetics Proto-Oncogene Protein c-ets-2 Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins c-ets Proto-Oncogenes* Repressor Proteins* Restriction Mapping Sequence Homology, Nucleic Acid Trans-Activators* Transcription Factors*|
|WOS Category||MULTIDISCIPLINARY SCIENCES|