RRC ID 30415
著者 Fujikawa K, Fort FL, Samejima K, Sakamoto Y.
タイトル Genotoxic potency in Drosophila melanogaster of selected aromatic amines and polycyclic aromatic hydrocarbons as assayed in the DNA repair test.
ジャーナル Mutat Res
Abstract Drosophila melanogaster stock consisting of meiotic recombination deficient (Rec-) double mutant mei-9a mei-41D5 males and Rec+ females was exposed at the larval stage to an aromatic amine or a polycyclic aromatic hydrocarbon. After emergence as adult flies, the males and the females were scored separately. When the treatment caused a dose-dependent reduction in the male to female ratio from the control level; the experiment was repeated with a larval stock consisting of Rec+ males and Rec+ females under comparable conditions. A preferential killing effect upon Rec- larvae was taken as evidence of DNA damaging effect of the test compound. Among 16 compounds tested, 1-AP, B(a)P, 2-AF, DAF, 4-AAF, 2-AAF, 1-AA, 2-AA, DMA, B(a)A and DMBA were registered as positive; Py and 3-MC were weakly positive; and B(e)P, Fluo and Ant were negative. The selective killing effects of the compounds in each of the pyrene, fluorene and anthracene series varied drastically as a function of structure in a way similar to that reported for the genotoxicity in Drosophila and the carcinogenicity in rodents. The Drosophila DNA repair assay will serve as a simple adjunct to the already available means for studying the genotoxic potency of aromatic amines and polycyclic aromatic hydrocarbons.
巻・号 290(2)
ページ 175-82
公開日 1993-12-1
DOI 10.1016/0027-5107(93)90157-b
PII 0027-5107(93)90157-B
PMID 7694108
MeSH 2-Acetylaminofluorene / analogs & derivatives 2-Acetylaminofluorene / toxicity 9,10-Dimethyl-1,2-benzanthracene / toxicity Amines / toxicity* Animals Anthracenes / toxicity Benz(a)Anthracenes / toxicity Benzo(a)pyrene / toxicity DNA Repair* Dose-Response Relationship, Drug Drosophila melanogaster / drug effects* Drosophila melanogaster / genetics Female Fluorenes / toxicity Genes, Insect / drug effects* Larva / drug effects Male Methylcholanthrene / toxicity Mutagens / toxicity* Polycyclic Compounds / toxicity* Pyrenes / toxicity Sex Ratio
IF 2.463
引用数 49
WOS 分野 TOXICOLOGY GENETICS & HEREDITY
リソース情報
ショウジョウバエ DGRC#109611