Reference - Detail
| RRC ID | 30418 |
|---|---|
| Author | Hoshino M, Matsuzaki F, Nabeshima Y, Hama C. |
| Title | hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein. |
| Journal | Neuron |
| Abstract |
We have identified a gene, hikaru genki (hig), whose mutant phenotype includes abnormal locomotor behavior. Mutant first instar larvae have uncoordinated movements, and both larvae and adults have reduced locomotion. Sequence analyses revealed that this gene encodes a novel type of protein with a signal sequence, but without transmembrane regions. One of its domains has similarities with immunoglobulin domains; three or four regions are similar to a complement-binding domain found in complement-related proteins and selectins. In situ hybridization to embryos revealed that accumulation of the hig transcripts is restricted to subsets of cells in the CNS. Our data suggest that hig has a role in the development of CNS functions involved in locomotor activity. |
| Volume | 10(3) |
| Pages | 395-407 |
| Published | 1993-3-1 |
| DOI | 10.1016/0896-6273(93)90329-p |
| PII | 0896-6273(93)90329-P |
| PMID | 8461133 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Base Sequence Central Nervous System / cytology Central Nervous System / physiology* Chromosome Mapping Drosophila / embryology Drosophila / genetics* Drosophila Proteins* Embryo, Nonmammalian / metabolism Gene Expression Genes, Insect* Locomotion* Molecular Sequence Data Movement Disorders / genetics* Mutation Nerve Tissue Proteins / genetics* RNA, Messenger / metabolism Sequence Homology, Amino Acid Transcription, Genetic |
| IF | 14.415 |
| Times Cited | 34 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 1.0 |
| Resource | |
| Drosophila | DGRC#109573 DGRC#109581 |