RRC ID 30435
Author Awasaki T, Saito M, Sone M, Suzuki E, Sakai R, Ito K, Hama C.
Title The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension.
Journal Neuron
Abstract We identified the Drosophila trio gene, which encodes a Dbl family protein carrying two Dbl homology (DH) domains, each of which potentially activates Rho family GTPases. Trio was distributed along axons in the central nervous system (CNS) of embryos and was strongly expressed in subsets of brain regions, including the mushroom body (MB). Loss-of-function trio mutations resulted in the misdirection or stall of axons in embryos and also caused malformation of the MB. The MB phenotypes were attributed to alteration in the intrinsic nature of neurites, as revealed by clonal analyses. Thus, Trio is essential in order for neurites to faithfully extend on the correct pathways. In addition, the localization of Trio in the adult brain suggests its postdevelopmental role in neurite terminals.
Volume 26(1)
Pages 119-31
Published 2000-4
PII S0896-6273(00)81143-5
PMID 10798397
MeSH Animals Axons / physiology* Central Nervous System / embryology* Central Nervous System / physiology Drosophila / genetics Drosophila Proteins* Growth Cones / physiology* Guanine Nucleotide Exchange Factors* Molecular Sequence Data Neurites / physiology* Oligochaeta / genetics Phosphoproteins / genetics* Phosphoproteins / physiology Protein-Serine-Threonine Kinases / genetics* Protein-Serine-Threonine Kinases / physiology
IF 14.319
Times Cited 144
WOS Category NEUROSCIENCES
Resource
Drosophila DGRC#109570 DGRC#109577