Reference - Detail
| RRC ID | 30445 |
|---|---|
| Author | Dahanukar A, Foster K, van der Goes van Naters WM, Carlson JR. |
| Title | A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. |
| Journal | Nat Neurosci |
| Abstract |
We recently identified from the Drosophila genome database a large family of G protein-coupled receptor genes, the Gr genes, and predicted that they encode taste receptors on the basis of their structure and specificity of expression. The expression of Gr genes in gustatory neurons has subsequently been confirmed and 56 family members have been reported. Here we provide functional evidence that one Gr gene, Gr5a, encodes a taste receptor required for response to the sugar trehalose. In two different mutants that carry deletions in Gr5a, electrophysiological and behavioral responses to trehalose were diminished but the response to sucrose was unaffected. Transgenic rescue experiments showed that Gr5a confers response to trehalose. The results correlate a particular taste ligand with a Gr receptor and indicate a role for G protein-mediated signaling in the transduction of sweet taste in Drosophila. |
| Volume | 4(12) |
| Pages | 1182-6 |
| Published | 2001-12-1 |
| DOI | 10.1038/nn765 |
| PII | nn765 |
| PMID | 11704765 |
| MeSH | Action Potentials / drug effects Action Potentials / physiology Animals Animals, Genetically Modified / genetics Base Sequence / physiology Behavior, Animal / drug effects Behavior, Animal / physiology Codon / genetics Dose-Response Relationship, Drug Drosophila / cytology Drosophila / physiology* Food, Formulated GTP-Binding Proteins / drug effects GTP-Binding Proteins / genetics* GTP-Binding Proteins / metabolism Gene Deletion Gene Expression Regulation / physiology Genetic Linkage / physiology Male Mutation / physiology* Neurons, Afferent / drug effects Neurons, Afferent / physiology* Phenotype Protein Biosynthesis / physiology Receptors, Cell Surface / drug effects Receptors, Cell Surface / genetics* Receptors, Cell Surface / metabolism Sucrose / pharmacology Taste / drug effects Taste / physiology* Trehalose / genetics Trehalose / metabolism Trehalose / pharmacology* X Chromosome / genetics |
| IF | 20.071 |
| Times Cited | 181 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| Drosophila | DGRC#109671 |