RRC ID 30474
Author Kurusu M, Maruyama Y, Adachi Y, Okabe M, Suzuki E, Furukubo-Tokunaga K.
Title A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain.
Journal Dev. Biol.
Abstract The intrinsic neurons of mushroom bodies (MBs), centers of olfactory learning in the Drosophila brain, are generated by a specific set of neuroblasts (Nbs) that are born in the embryonic stage and exhibit uninterrupted proliferation till the end of the pupal stage. Whereas MB provides a unique model to study proliferation of neural progenitors, the underlying mechanism that controls persistent activity of MB-Nbs is poorly understood. Here we show that Tailless (TLL), a conserved orphan nuclear receptor, is required for optimum proliferation activity and prolonged maintenance of MB-Nbs and ganglion mother cells (GMCs). Mutations of tll progressively impair cell cycle in MB-Nbs and cause premature loss of MB-Nbs in the early pupal stage. TLL is also expressed in MB-GMCs to prevent apoptosis and promote cell cycling. In addition, we show that ectopic expression of tll leads to brain tumors, in which Prospero, a key regulator of progenitor proliferation and differentiation, is suppressed whereas localization of molecular components involved in asymmetric Nb division is unaffected. These results as a whole uncover a distinct regulatory mechanism of self-renewal and differentiation of the MB progenitors that is different from the mechanisms found in other progenitors.
Volume 326(1)
Pages 224-36
Published 2009-2-1
DOI 10.1016/j.ydbio.2008.11.013
PII S0012-1606(08)01359-6
PMID 19084514
MeSH Animals Apoptosis / physiology Brain Neoplasms / embryology Brain Neoplasms / genetics Brain Neoplasms / metabolism Cell Differentiation / physiology Cell Proliferation* DNA-Binding Proteins / genetics DNA-Binding Proteins / physiology* Drosophila / embryology* Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Ganglia, Invertebrate / embryology Ganglia, Invertebrate / growth & development Ganglia, Invertebrate / metabolism Mushroom Bodies / embryology* Mushroom Bodies / growth & development* Mushroom Bodies / metabolism Mutation Nerve Tissue Proteins / metabolism Neurons / cytology Neurons / physiology Nuclear Proteins / metabolism Repressor Proteins / genetics Repressor Proteins / physiology* Stem Cells / cytology Stem Cells / physiology Transcription Factors / metabolism
IF 2.936
Times Cited 32
WOS Category DEVELOPMENTAL BIOLOGY
Resource
Drosophila DGRC#109680