論文 - 詳細
| RRC ID | 30629 |
|---|---|
| 著者 | Beets I, Janssen T, Meelkop E, Temmerman L, Suetens N, Rademakers S, Jansen G, Schoofs L. |
| タイトル | Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans. |
| ジャーナル | Science |
| Abstract |
Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction. Although these neuropeptides also modulate social behavior and cognition in mammals, the mechanism for influencing behavioral plasticity and the evolutionary origin of these effects are not well understood. Here, we present a functional vasopressin- and oxytocin-like signaling system in the nematode Caenorhabditis elegans. Through activation of its receptor NTR-1, a vasopressin/oxytocin-related neuropeptide, designated nematocin, facilitates the experience-driven modulation of salt chemotaxis, a type of gustatory associative learning in C. elegans. Our study suggests that vasopressin and oxytocin neuropeptides have ancient roles in modulating sensory processing in neural circuits that underlie behavioral plasticity. |
| 巻・号 | 338(6106) |
| ページ | 543-5 |
| 公開日 | 2012-10-26 |
| DOI | 10.1126/science.1226860 |
| PII | 338/6106/543 |
| PMID | 23112336 |
| MeSH | Amino Acid Sequence Animals Biological Evolution Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / agonists Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / pharmacology Caenorhabditis elegans Proteins / physiology* Learning / drug effects Learning / physiology* Male Molecular Sequence Data Neuropeptides / chemistry Neuropeptides / genetics Neuropeptides / pharmacology Neuropeptides / physiology* Oxytocin / chemistry Oxytocin / genetics Oxytocin / pharmacology Oxytocin / physiology* Receptors, G-Protein-Coupled / agonists Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / metabolism Receptors, G-Protein-Coupled / physiology* Signal Transduction Taste / drug effects Taste / physiology* Vasopressins / chemistry Vasopressins / genetics Vasopressins / pharmacology Vasopressins / physiology* |
| IF | 41.846 |
| 引用数 | 94 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm2765 |