Reference - Detail
| RRC ID | 30631 |
|---|---|
| Author | Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C. |
| Title | RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. |
| Journal | Science |
| Abstract |
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-β-catenin network, where it acts as a regulatory subunit of CK1ε: In a Wnt-dependent manner, DDX3 binds CK1ε and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-β-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families. |
| Volume | 339(6126) |
| Pages | 1436-41 |
| Published | 2013-3-22 |
| DOI | 10.1126/science.1231499 |
| PII | science.1231499 |
| PMID | 23413191 |
| MeSH | Adaptor Proteins, Signal Transducing / metabolism Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Casein Kinase 1 epsilon / chemistry Casein Kinase 1 epsilon / metabolism* DEAD-box RNA Helicases / chemistry DEAD-box RNA Helicases / genetics DEAD-box RNA Helicases / metabolism* Dishevelled Proteins HEK293 Cells Humans Phosphoproteins / metabolism Phosphorylation Protein Binding Protein Structure, Tertiary RNA Helicases / chemistry RNA Helicases / genetics RNA Helicases / metabolism* Wnt Proteins / metabolism Wnt Signaling Pathway* Xenopus / embryology Xenopus / genetics Xenopus / metabolism Xenopus Proteins / chemistry Xenopus Proteins / genetics Xenopus Proteins / metabolism* beta Catenin / metabolism |
| IF | 41.846 |
| Times Cited | 115 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| C.elegans | tm1320 |