論文 - 詳細
| RRC ID | 30640 |
|---|---|
| 著者 | Watson E, MacNeil LT, Arda HE, Zhu LJ, Walhout AJM. |
| タイトル | Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. |
| ジャーナル | Cell |
| Abstract |
Expression profiles are tailored according to dietary input. However, the networks that control dietary responses remain largely uncharacterized. Here, we combine forward and reverse genetic screens to delineate a network of 184 genes that affect the C. elegans dietary response to Comamonas DA1877 bacteria. We find that perturbation of a mitochondrial network composed of enzymes involved in amino acid metabolism and the TCA cycle affects the dietary response. In humans, mutations in the corresponding genes cause inborn diseases of amino acid metabolism, most of which are treated by dietary intervention. We identify several transcription factors (TFs) that mediate the changes in gene expression upon metabolic network perturbations. Altogether, our findings unveil a transcriptional response system that is poised to sense dietary cues and metabolic imbalances, illustrating extensive communication between metabolic networks in the mitochondria and gene regulatory networks in the nucleus. |
| 巻・号 | 153(1) |
| ページ | 253-66 |
| 公開日 | 2013-3-28 |
| DOI | 10.1016/j.cell.2013.02.050 |
| PII | S0092-8674(13)00284-5 |
| PMID | 23540702 |
| PMC | PMC3817025 |
| MeSH | Acyl-CoA Dehydrogenase / metabolism Animals Betaproteobacteria Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Diet Escherichia coli Gene Regulatory Networks* Humans Insulin / metabolism Metabolic Networks and Pathways* Metabolism, Inborn Errors Mitochondria / metabolism Phosphotransferases (Alcohol Group Acceptor) / metabolism RNA Interference Signal Transduction Transcription Factors / metabolism |
| IF | 38.637 |
| 引用数 | 59 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4695 |