論文 - 詳細
| RRC ID | 30645 |
|---|---|
| 著者 | Hadziselimovic N, Vukojevic V, Peter F, Milnik A, Fastenrath M, Fenyves BG, Hieber P, Demougin P, Vogler C, de Quervain DJ, Papassotiropoulos A, Stetak A. |
| タイトル | Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex. |
| ジャーナル | Cell |
| Abstract |
A plastic nervous system requires the ability not only to acquire and store but also to forget. Here, we report that musashi (msi-1) is necessary for time-dependent memory loss in C. elegans. Tissue-specific rescue demonstrates that MSI-1 function is necessary in the AVA interneuron. Using RNA-binding protein immunoprecipitation (IP), we found that MSI-1 binds to mRNAs of three subunits of the Arp2/3 actin branching regulator complex in vivo and downregulates ARX-1, ARX-2, and ARX-3 translation upon associative learning. The role of msi-1 in forgetting is also reflected by the persistence of learning-induced GLR-1 synaptic size increase in msi-1 mutants. We demonstrate that memory length is regulated cooperatively through the activation of adducin (add-1) and by the inhibitory effect of msi-1. Thus, a GLR-1/MSI-1/Arp2/3 pathway induces forgetting and represents a novel mechanism of memory decay by linking translational control to the structure of the actin cytoskeleton in neurons. |
| 巻・号 | 156(6) |
| ページ | 1153-1166 |
| 公開日 | 2014-3-13 |
| DOI | 10.1016/j.cell.2014.01.054 |
| PII | S0092-8674(14)00148-2 |
| PMID | 24630719 |
| MeSH | Actin-Related Protein 2-3 Complex / genetics* Actin-Related Protein 2-3 Complex / metabolism Actins / metabolism Amino Acid Sequence Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Interneurons / metabolism* Memory* Molecular Sequence Data Mutation Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Protein Biosynthesis RNA, Helminth / metabolism* RNA, Messenger / metabolism RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism* Sequence Alignment Synapses |
| IF | 38.637 |
| 引用数 | 45 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 85 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3760 |