RRC ID 30686
Author Hedengren M, Asling B, Dushay MS, Ando I, Ekengren S, Wihlborg M, Hultmark D.
Title Relish, a central factor in the control of humoral but not cellular immunity in Drosophila.
Journal Mol Cell
Abstract The NF-kappa B-like Relish gene is complex, with four transcripts that are all located within an intron of the Nmdmc gene. Using deletion mutants, we show that Relish is specifically required for the induction of the humoral immune response, including both antibacterial and antifungal peptides. As a result, the Relish mutants are very sensitive to infection. A single cell of E. cloacae is sufficient to kill a mutant fly, and the mutants show increased susceptibility to fungal infection. In contrast, the blood cell population, the hematopoietic organs, and the phagocytic, encapsulation, and melanization responses are normal. Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that Relish plays a key role in this response.
Volume 4(5)
Pages 827-37
Published 1999-11-1
DOI 10.1016/s1097-2765(00)80392-5
PII S1097-2765(00)80392-5
PMID 10619029
MeSH Animals Anti-Bacterial Agents Anti-Infective Agents / metabolism Antibody Formation / genetics Antibody Formation / immunology* Antifungal Agents / metabolism Bacteria / immunology Cloning, Molecular Drosophila Proteins* Drosophila melanogaster / cytology Drosophila melanogaster / genetics Drosophila melanogaster / immunology* Drosophila melanogaster / microbiology Exons / genetics Fungi / immunology Genes, Insect / genetics Genes, Insect / physiology Hemocytes / immunology Immunity, Cellular / genetics Immunity, Cellular / immunology* Introns / genetics Larva / cytology Larva / immunology Larva / microbiology Models, Immunological Molecular Sequence Data Peptides / genetics Peptides / metabolism Phagocytosis / immunology Sequence Deletion / genetics Signal Transduction Transcription Factors / genetics Transcription Factors / immunology* Up-Regulation
IF 15.584
Times Cited 363