論文 - 詳細
| RRC ID | 30721 |
|---|---|
| 著者 | Lilue J, Müller UB, Steinfeldt T, Howard JC. |
| タイトル | Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse. |
| ジャーナル | Elife |
| Abstract |
Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI:http://dx.doi.org/10.7554/eLife.01298.001. |
| 巻・号 | 2 |
| ページ | e01298 |
| 公開日 | 2013-10-29 |
| DOI | 10.7554/eLife.01298 |
| PII | 01298 |
| PMID | 24175088 |
| PMC | PMC3810784 |
| MeSH | Animals Animals, Wild / genetics* Animals, Wild / immunology Animals, Wild / parasitology Binding Sites Biological Evolution Genetic Loci Haplotypes Host-Parasite Interactions Hydro-Lyases / chemistry Hydro-Lyases / genetics* Hydro-Lyases / metabolism Mice Models, Molecular Polymorphism, Genetic Protein Binding Protein Isoforms / chemistry Protein Isoforms / genetics Protein Isoforms / metabolism Protein Kinases / chemistry Protein Kinases / genetics* Protein Kinases / metabolism Protozoan Proteins / chemistry Protozoan Proteins / genetics* Protozoan Proteins / metabolism Toxoplasma / genetics* Toxoplasma / immunology Toxoplasma / pathogenicity Toxoplasmosis, Animal / genetics* Toxoplasmosis, Animal / immunology Toxoplasmosis, Animal / parasitology Virulence / genetics |
| IF | 7.08 |
| 引用数 | 53 |
| WOS 分野 | BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | MSM Mouse BAC (RDB04214) MSMg01-329H21 MSMg01-362F04 MSMg01-544P17 MSMg01-494M12 MSMg01-419B05 MSMg01-148E20 MSMg01-355D01. |