RRC ID |
30721
|
著者 |
Lilue J, Müller UB, Steinfeldt T, Howard JC.
|
タイトル |
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse.
|
ジャーナル |
Elife
|
Abstract |
Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI:http://dx.doi.org/10.7554/eLife.01298.001.
|
巻・号 |
2
|
ページ |
e01298
|
公開日 |
2013-10-29
|
DOI |
10.7554/eLife.01298
|
PII |
01298
|
PMID |
24175088
|
PMC |
PMC3810784
|
MeSH |
Animals
Animals, Wild / genetics*
Animals, Wild / immunology
Animals, Wild / parasitology
Binding Sites
Biological Evolution
Genetic Loci
Haplotypes
Host-Parasite Interactions
Hydro-Lyases / chemistry
Hydro-Lyases / genetics*
Hydro-Lyases / metabolism
Mice
Models, Molecular
Polymorphism, Genetic
Protein Binding
Protein Isoforms / chemistry
Protein Isoforms / genetics
Protein Isoforms / metabolism
Protein Kinases / chemistry
Protein Kinases / genetics*
Protein Kinases / metabolism
Protozoan Proteins / chemistry
Protozoan Proteins / genetics*
Protozoan Proteins / metabolism
Toxoplasma / genetics*
Toxoplasma / immunology
Toxoplasma / pathogenicity
Toxoplasmosis, Animal / genetics*
Toxoplasmosis, Animal / immunology
Toxoplasmosis, Animal / parasitology
Virulence / genetics
|
IF |
7.08
|
引用数 |
53
|
WOS 分野
|
BIOLOGY
|
リソース情報 |
遺伝子材料 |
MSM Mouse BAC (RDB04214) MSMg01-329H21
MSMg01-362F04
MSMg01-544P17
MSMg01-494M12
MSMg01-419B05
MSMg01-148E20
MSMg01-355D01. |