論文 - 詳細
| RRC ID | 30920 |
|---|---|
| 著者 | Horie Y, Kobayashi T. |
| タイトル | Relationships between gonadal and gonadotrophic differentiation during early gonadal sex differentiation in several strains from the Southern population of Japanese medaka (Oryzias latipes). |
| ジャーナル | J Exp Zool A Ecol Genet Physiol |
| Abstract |
In this study, correlations between gonadal differentiation and gonadotrophic differentiation during early gonadal sex differentiation were examined in several strains from the Southern population of Japanese medaka, namely, Hd-rR, d-rR/Tokyo, d-rR/Shizuoka, and NIESR. Gonadal sex differentiation showed a similar pattern in all strains, that is, a sex-based difference in germ cell number was observed at hatching (XX > XY). In addition, a transition of XX germ cells into meiosis was observed at hatching in all strains. However, the ratio of meiotic transition of XX germ cells differed among strains, indicating that Hd-rR has fewer meiotic cells than other strains. Immunohistochemical analysis showed that glycoprotein α subunit (Gpa) and follicle-stimulating hormone β subunit (Fshb), but not luteinizing hormone β subunit (Lhb), localize to the pituitary at hatching in all strains examined. Although no sex differences were observed in the numbers of Gpa- and Fshb-positive cells in the pituitary at hatching in Hd-rR, d-rR/Tokyo, and NIESR strains, the d-rR/Shizuoka strain showed sex differences in the number of Fshb-positive cells at hatching (XX > XY); d-rR/Shizuoka is derived from d-rR/Tokyo. Even though d-rR/Shizuoka differs from its ancestral strain, d-rR/Tokyo, and Hd-rR in Fshb expression pattern, this suggests that d-rR/Shizuoka shows potential for use as a model to study the molecular regulatory mechanisms of fshb subunit gene expression and Fsh cell differentiation in the pituitary. |
| 巻・号 | 321(8) |
| ページ | 472-7 |
| 公開日 | 2014-10-1 |
| DOI | 10.1002/jez.1879 |
| PMID | 25078094 |
| MeSH | Animals Cell Differentiation Female Follicle Stimulating Hormone, beta Subunit / genetics Follicle Stimulating Hormone, beta Subunit / metabolism Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology Germ Cells Glycoprotein Hormones, alpha Subunit / genetics Glycoprotein Hormones, alpha Subunit / metabolism Gonads / growth & development* Luteinizing Hormone, beta Subunit / genetics Luteinizing Hormone, beta Subunit / metabolism Male Oryzias / genetics Oryzias / physiology* Pituitary Gland / cytology Pituitary Gland / metabolism Sex Chromosomes / genetics Sex Differentiation / genetics Sex Differentiation / physiology* |
| IF | 1.917 |
| 引用数 | 2 |
| WOS 分野 | ZOOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | d-rR/TOKYO (MT837) HdrR-II1 (IB178) |