| RRC ID |
31374
|
| Author |
Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y.
|
| Title |
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
|
| Journal |
Development
|
| Abstract |
We here report essential roles of the Bmp-binding protein crossveinless 2 (Cv2; Bmper) in mouse organogenesis. In the null Cv2 mutant mouse, gastrulation occurs normally, but a number of defects are found in Cv2-expressing tissues such as the skeleton. Cartilage differentiation by Bmp4 treatment is reduced in cultured Cv2(-/-) fibroblasts. Moreover, the defects in the vertebral column and eyes of the Cv2(-/-) mouse are substantially enhanced by deleting one copy of the Bmp4 gene, suggesting a pro-Bmp role of Cv2 in the development of these organs. In addition, the Cv2(-/-) mutant exhibits substantial defects in Bmp-dependent processes of internal organ formation, such as nephron generation in the kidney. This kidney hypoplasia is synergistically enhanced by the additional deletion of Kcp (Crim2) which encodes a pro-Bmp protein structurally related to Cv2. This study demonstrates essential pro-Bmp functions of Cv2 for locally restricted signal enhancement in multiple aspects of mammalian organogenesis.
|
| Volume |
133(22)
|
| Pages |
4463-73
|
| Published |
2006-11-1
|
| DOI |
10.1242/dev.02647
|
| PII |
dev.02647
|
| PMID |
17035289
|
| MeSH |
Animals
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Cartilage / embryology*
DNA Primers
Eye / embryology*
Immunohistochemistry
Kidney / embryology*
Mice
Mice, Knockout
Mice, Mutant Strains
Organogenesis / physiology*
Phenotype*
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / physiology*
|
| IF |
5.611
|
| Times Cited |
87
|
|
WOS Category
|
DEVELOPMENTAL BIOLOGY
|
| Resource |
| DNA material |
nBLUEneo (RDB07039). |
