論文 - 詳細
| RRC ID | 31374 |
|---|---|
| 著者 | Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. |
| タイトル | Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. |
| ジャーナル | Development |
| Abstract |
We here report essential roles of the Bmp-binding protein crossveinless 2 (Cv2; Bmper) in mouse organogenesis. In the null Cv2 mutant mouse, gastrulation occurs normally, but a number of defects are found in Cv2-expressing tissues such as the skeleton. Cartilage differentiation by Bmp4 treatment is reduced in cultured Cv2(-/-) fibroblasts. Moreover, the defects in the vertebral column and eyes of the Cv2(-/-) mouse are substantially enhanced by deleting one copy of the Bmp4 gene, suggesting a pro-Bmp role of Cv2 in the development of these organs. In addition, the Cv2(-/-) mutant exhibits substantial defects in Bmp-dependent processes of internal organ formation, such as nephron generation in the kidney. This kidney hypoplasia is synergistically enhanced by the additional deletion of Kcp (Crim2) which encodes a pro-Bmp protein structurally related to Cv2. This study demonstrates essential pro-Bmp functions of Cv2 for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. |
| 巻・号 | 133(22) |
| ページ | 4463-73 |
| 公開日 | 2006-11-1 |
| DOI | 10.1242/dev.02647 |
| PII | dev.02647 |
| PMID | 17035289 |
| MeSH | Animals Carrier Proteins / genetics Carrier Proteins / metabolism* Cartilage / embryology* DNA Primers Eye / embryology* Immunohistochemistry Kidney / embryology* Mice Mice, Knockout Mice, Mutant Strains Organogenesis / physiology* Phenotype* Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / physiology* |
| IF | 5.611 |
| 引用数 | 87 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | nBLUEneo (RDB07039). |