論文 - 詳細
RRC ID | 31383 |
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著者 | Tsuda M, Seong KH, Aigaki T. |
タイトル | POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. |
ジャーナル | FEBS Lett |
Abstract |
Plenty of SH3s (POSH) functions as a scaffold protein for the Jun N-terminal kinase (JNK) signal transduction pathway, which leads to cell death in mammalian cultured cells and Drosophila. Here, we show that POSH forms a complex with Apoptosis-linked gene-2 (ALG-2) and ALG-2-interacting protein (ALIX/AIP1) in a calcium-dependent manner. Overexpression of ALG-2 or ALIX in developing imaginal eye discs resulted in roughened or melanized eyes, respectively. These phenotypes were enhanced by co-overexpression of POSH. We found that overexpression of either gene could induce ectopic JNK activation, suggesting that POSH/ALG-2/ALIX may function together in the regulation of the JNK pathway. |
巻・号 | 580(13) |
ページ | 3296-300 |
公開日 | 2006-5-29 |
DOI | 10.1016/j.febslet.2006.05.005 |
PII | S0014-5793(06)00573-4 |
PMID | 16698022 |
MeSH | Animals Calcium-Binding Proteins / genetics Calcium-Binding Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cytoskeletal Proteins / genetics Cytoskeletal Proteins / metabolism* Drosophila / chemistry Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Eye / anatomy & histology Eye / growth & development Eye / metabolism Gene Expression Regulation, Developmental Immunoprecipitation MAP Kinase Kinase 4 / metabolism Microfilament Proteins / genetics Microfilament Proteins / metabolism* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Protein Interaction Mapping RNA, Messenger / analysis RNA, Messenger / metabolism |
IF | 3.057 |
引用数 | 33 |
WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
ショウジョウバエ |