論文 - 詳細
| RRC ID | 31888 |
|---|---|
| 著者 | Speitling M, Nattewan P, Yazawa K, Mikami Y, Grün-Wollny I, Ritzau M, Laatsch H, Gräfe U. |
| タイトル | Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa tumor cells (IC50; 9.6, >25 and 20 microg/ml, respectively). |
| 巻・号 | 51(8) |
| ページ | 693-8 |
| 公開日 | 1998-8-1 |
| DOI | 10.7164/antibiotics.51.693 |
| PMID | 9766460 |
| MeSH | Animals Anthracyclines* Antibiotics, Antineoplastic / chemistry Antibiotics, Antineoplastic / isolation & purification* Antibiotics, Antineoplastic / pharmacology* Fermentation Gram-Positive Bacteria / drug effects HeLa Cells / drug effects Humans Leukemia L1210 / drug therapy Leukemia P388 / drug therapy Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Nocardia Stereoisomerism Streptomyces Structure-Activity Relationship |
| IF | 2.668 |
| 引用数 | 11 |
| WOS 分野 | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | IFM 0456 IFM 20572057 |