RRC ID 31894
Author Yazawa K, Mikami Y, Maeda A, Morisaki N, Iwasaki S.
Title Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum.
Journal J. Antimicrob. Chemother.
Abstract Rifampicin was inactivated by Nocardia otitidiscaviarum to yield two products designated RIP-3 and RIP-4. The full structures of RIP-3 and RIP-4 were determined to be 21-(O-phosphoryl) rifampicin and 3-formyl-21-(O-phosphoryl) rifamycin SV, respectively, but neither product had any antimicrobial activity.
Volume 33(6)
Pages 1127-35
Published 1994-6
PMID 7928806
MeSH Biotransformation Corynebacterium / drug effects Drug Resistance, Microbial Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Nocardia / drug effects Nocardia / metabolism* Phosphorylation Rhodococcus / drug effects Rifampin / analogs & derivatives Rifampin / chemistry Rifampin / metabolism* Rifampin / pharmacokinetics* Rifampin / pharmacology Staphylococcus aureus / drug effects
IF 5.217
Times Cited 29
WOS Category PHARMACOLOGY & PHARMACY INFECTIOUS DISEASES MICROBIOLOGY
Resource
Pathogenic microorganisms IFM 0150 IFM 0236 IFM 0239 IFM 0290 IFM 0319 IFM 2057