RRC ID 31934
Author Tanaka Y, Gräfe U, Yazawa K, Mikami Y, Ritzau M.
Title Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis.
Journal J. Antibiot.
Abstract Nocardicyclins A (1) and B (2), new anthracycline antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894). The molecular formulae of 1 and 2 have been determined as C30H35NO11 and C32H37NO12, respectively, and the structures were characterized by 1- and 8-methoxyl groups, a 10-carbonyl group and a novel carbon-methylated aminosugar constituent. Nocardicyclin A (1) exerts cytotoxic activity against L1210 and P388 leukemia. Nocardicyclins A (1) and B (2) are active against Gram-positive bacteria including Mycobacterium spp. and Nocardia spp., but inactive against Gram-negative bacteria.
Volume 50(10)
Pages 822-7
Published 1997-10
PMID 9402986
MeSH Anthracyclines* Antibiotics, Antineoplastic / chemistry* Antibiotics, Antineoplastic / metabolism Antibiotics, Antineoplastic / pharmacology* Fermentation Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure Nocardia / chemistry Nocardia / metabolism*
IF 2.033
Times Cited 30
WOS Category PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY
Resource
Pathogenic microorganisms IFM 0236 IFM 0239 IFM 0284 IFM 0290 IFM 0319 IFM 0333 IFM 0623 IFM 0624 IFM 40213