RRC ID 31978
Author Mondal BC, Shim J, Evans CJ, Banerjee U.
Title Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors.
Journal Elife
Abstract Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the 'equilibrium signal' in order to distinguish it from the 'niche signal'. Earlier we showed that equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and adenosine deaminase-related growth factor A (ADGF-A) (Mondal et al., 2011). Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric à brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.
Volume 3
Pages e03626
Published 2014-9-8
DOI 10.7554/eLife.03626
PMID 25201876
PMC PMC4185420
MeSH Animals Cell Differentiation / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Genes, Insect Genetic Association Studies Genetic Testing Hematopoiesis Hematopoietic Stem Cells / cytology* Hematopoietic Stem Cells / metabolism* Lymph Nodes / cytology Models, Biological Phenotype RNA Interference Receptor Protein-Tyrosine Kinases / metabolism* Reproducibility of Results Signal Transduction* / genetics
IF 7.616
Times Cited 14
Drosophila 7574R-2 10198R-1 12030R-2 12765R-3