論文 - 詳細
| RRC ID | 320 |
|---|---|
| 著者 | Ishimaru S, Ueda R, Hinohara Y, Ohtani M, Hanafusa H. |
| タイトル | PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. |
| ジャーナル | EMBO J |
| Abstract |
PVR, the Drosophila homolog of the PDGF/VEGF receptor, has been implicated in border cell migration during oogenesis and hemocyte migration during embryogenesis. It was earlier shown that Mbc, a CDM family protein, and its effector, Rac, transduced the guidance signal from PVR during border cell migration. Here we demonstrate that PVR is also required for the morphogenetic process, thorax closure, during metamorphosis. The results of genetic and biochemical experiments indicate that PVR activates the JNK pathway. We present evidence showing Crk (an adaptor molecule), Mbc, ELMO (a homolog of Caenorhabditis elegans CED-12 and mammalian ELMO), and Rac to be mediators of JNK activation by PVR. In addition, we suppose that not only Rac but also Cdc42 is activated and involved in JNK activation downstream of PVR. |
| 巻・号 | 23(20) |
| ページ | 3984-94 |
| 公開日 | 2004-10-13 |
| DOI | 10.1038/sj.emboj.7600417 |
| PII | 7600417 |
| PMID | 15457211 |
| PMC | PMC524349 |
| MeSH | Animals Cells, Cultured Cytoskeletal Proteins / metabolism Drosophila / cytology Drosophila / growth & development* Drosophila / physiology Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Embryo, Nonmammalian Insect Proteins / chemistry Insect Proteins / genetics Insect Proteins / metabolism* JNK Mitogen-Activated Protein Kinases / metabolism* Metamorphosis, Biological* Morphogenesis* RNA Interference Receptor Protein-Tyrosine Kinases / chemistry Receptor Protein-Tyrosine Kinases / genetics Receptor Protein-Tyrosine Kinases / metabolism* Signal Transduction Transgenes cdc42 GTP-Binding Protein / metabolism rac GTP-Binding Proteins / metabolism |
| IF | 9.889 |
| 引用数 | 78 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | 2190R-1 2190R-2 5680R-1 5680R-2 8222R-2 8222R-3 10379R-1 10379R-3 5336R-2 5336R-3 4353R-2 4353R-3 |