RRC ID 32000
Author Kato M, Tsuji-Kawahara S, Kawasaki Y, Kinoshita S, Chikaishi T, Takamura S, Fujisawa M, Kawada A, Miyazawa M.
Title Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.
Journal J Virol
Abstract Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4+ T cells.
Volume 89(2)
Pages 1468-73
Published 2015-1-15
DOI 10.1128/JVI.02293-14
PII JVI.02293-14
PMID 25378499
PMC PMC4300674
MeSH Animals Antibodies, Neutralizing / blood* Antibodies, Viral / blood* CD4-Positive T-Lymphocytes / immunology Cytidine Deaminase / deficiency Friend murine leukemia virus / immunology* Immunization, Passive Immunoglobulin Class Switching Immunoglobulin M / immunology Leukemia, Experimental / immunology* Leukemia, Experimental / virology Mice Retroviridae Infections / immunology* Retroviridae Infections / virology Somatic Hypermutation, Immunoglobulin* Tumor Virus Infections / immunology* Tumor Virus Infections / virology
IF 4.501
Times Cited 5
Mice RBRC00897 RBRC00901