RRC ID 32231
Author Hirawatari K, Hanzawa N, Kuwahara M, Aoyama H, Miura I, Wakana S, Gotoh H.
Title Polygenic expression of teratozoospermia and normal fertility in B10.MOL-TEN1 mouse strain.
Journal Congenit Anom (Kyoto)
Abstract Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B10.MOL-TEN1 mice, which shows high-frequencies (about 50%) of morphologically abnormal sperm. Drastic histological changes were also found in the testis of the B10.MOL-TEN1. Segregation analysis showed that the abnormal sperm phenotype in B10.MOL-TEN1 was inherited and was predictably controlled by at least three loci. We also found that male fertility of this strain was normal. These findings indicate a complicated relationship between sperm morphology and male subfertility.
Volume 55(2)
Pages 92-8
Published 2015-5-1
DOI 10.1111/cga.12102
PMID 25559406
PMC PMC6680107
MeSH Animals Chromosome Mapping Female Fertility / genetics* Genetic Linkage Male Mice Multifactorial Inheritance* Phenotype Sperm Count Sperm Head / pathology Spermatozoa / metabolism* Spermatozoa / pathology* Testis / metabolism
IF 1.761
Times Cited 2
Mice RBRC00494