| RRC ID |
32496
|
| 著者 |
Lin ST, Zhang L, Lin X, Zhang LC, Garcia VE, Tsai CW, Ptáček L, Fu YH.
|
| タイトル |
Nuclear envelope protein MAN1 regulates clock through BMAL1.
|
| ジャーナル |
Elife
|
| Abstract |
Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks of feedback loops that fine-tune circadian processes. Our knowledge of these components and pathways is far from exhaustive. In recent decades, the nuclear envelope has emerged as a global gene regulatory machine, although its role in circadian regulation has not been explored. We report that transcription of the core clock component BMAL1 is positively modulated by the inner nuclear membrane protein MAN1, which directly binds the BMAL1 promoter and enhances its transcription. Our results establish a novel connection between the nuclear periphery and circadian rhythmicity, therefore bridging two global regulatory systems that modulate all aspects of bodily functions.
|
| 巻・号 |
3
|
| ページ |
e02981
|
| 公開日 |
2014-9-2
|
| DOI |
10.7554/eLife.02981
|
| PMID |
25182847
|
| PMC |
PMC4150126
|
| MeSH |
ARNTL Transcription Factors / genetics*
ARNTL Transcription Factors / metabolism
Animals
Blotting, Western
Cell Line, Tumor
Circadian Clocks / genetics*
DNA-Binding Proteins
Gene Expression Regulation*
HEK293 Cells
Humans
Lamin Type B / genetics
Lamin Type B / metabolism
Membrane Proteins / genetics*
Membrane Proteins / metabolism
Mice, Inbred C57BL
Mice, Knockout
Nuclear Envelope / metabolism
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Promoter Regions, Genetic / genetics
Protein Binding
RNA Interference
Reverse Transcriptase Polymerase Chain Reaction
|
| IF |
7.08
|
| 引用数 |
14
|
|
WOS 分野
|
BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
DGRC#200396
DGRC#205055
3167R-1 |
