論文 - 詳細
| RRC ID | 32511 |
|---|---|
| 著者 | Yamagata N, Ichinose T, Aso Y, Plaçais PY, Friedrich AB, Sima RJ, Preat T, Rubin GM, Tanimoto H. |
| タイトル | Distinct dopamine neurons mediate reward signals for short- and long-term memories. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Drosophila melanogaster can acquire a stable appetitive olfactory memory when the presentation of a sugar reward and an odor are paired. However, the neuronal mechanisms by which a single training induces long-term memory are poorly understood. Here we show that two distinct subsets of dopamine neurons in the fly brain signal reward for short-term (STM) and long-term memories (LTM). One subset induces memory that decays within several hours, whereas the other induces memory that gradually develops after training. They convey reward signals to spatially segregated synaptic domains of the mushroom body (MB), a potential site for convergence. Furthermore, we identified a single type of dopamine neuron that conveys the reward signal to restricted subdomains of the mushroom body lobes and induces long-term memory. Constant appetitive memory retention after a single training session thus comprises two memory components triggered by distinct dopamine neurons. |
| 巻・号 | 112(2) |
| ページ | 578-83 |
| 公開日 | 2015-1-13 |
| DOI | 10.1073/pnas.1421930112 |
| PII | 1421930112 |
| PMID | 25548178 |
| PMC | PMC4299218 |
| MeSH | Animals Animals, Genetically Modified Appetitive Behavior / physiology Carbohydrates Dopaminergic Neurons / physiology* Drosophila melanogaster / anatomy & histology Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Learning / physiology Memory, Long-Term / physiology Memory, Short-Term / physiology Mushroom Bodies / physiology Odorants Reward Smell / physiology Taste / physiology |
| IF | 9.412 |
| 引用数 | 89 |
| WOS 分野 | NEUROSCIENCES |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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