RRC ID 32511
Author Yamagata N, Ichinose T, Aso Y, Plaçais PY, Friedrich AB, Sima RJ, Preat T, Rubin GM, Tanimoto H.
Title Distinct dopamine neurons mediate reward signals for short- and long-term memories.
Journal Proc. Natl. Acad. Sci. U.S.A.
Abstract Drosophila melanogaster can acquire a stable appetitive olfactory memory when the presentation of a sugar reward and an odor are paired. However, the neuronal mechanisms by which a single training induces long-term memory are poorly understood. Here we show that two distinct subsets of dopamine neurons in the fly brain signal reward for short-term (STM) and long-term memories (LTM). One subset induces memory that decays within several hours, whereas the other induces memory that gradually develops after training. They convey reward signals to spatially segregated synaptic domains of the mushroom body (MB), a potential site for convergence. Furthermore, we identified a single type of dopamine neuron that conveys the reward signal to restricted subdomains of the mushroom body lobes and induces long-term memory. Constant appetitive memory retention after a single training session thus comprises two memory components triggered by distinct dopamine neurons.
Volume 112(2)
Pages 578-83
Published 2015-1-13
DOI 10.1073/pnas.1421930112
PII 1421930112
PMID 25548178
PMC PMC4299218
MeSH Animals Animals, Genetically Modified Appetitive Behavior / physiology Carbohydrates Dopaminergic Neurons / physiology* Drosophila melanogaster / anatomy & histology Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Learning / physiology Memory, Long-Term / physiology Memory, Short-Term / physiology Mushroom Bodies / physiology Odorants Reward Smell / physiology Taste / physiology
IF 9.58
Times Cited 34
WOS Category NEUROSCIENCES
Resource
Drosophila