RRC ID 32527
Author Ma Q, Wawersik M, Matunis EL.
Title The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche.
Journal Dev Cell
Abstract Local signals maintain adult stem cells in many tissues. Whether the sexual identity of adult stem cells must also be maintained was not known. In the adult Drosophila testis niche, local Jak-STAT signaling promotes somatic cyst stem cell (CySC) renewal through several effectors, including the putative transcription factor Chronologically inappropriate morphogenesis (Chinmo). Here, we find that Chinmo also prevents feminization of CySCs. Chinmo promotes expression of the canonical male sex determination factor DoublesexM (Dsx(M)) within CySCs and their progeny, and ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of Dsx(M). The Dsx homolog DMRT1 prevents the male-to-female conversion of differentiated somatic cells in the adult mammalian testis, but its regulation is not well understood. Our work indicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved process is governed by effectors of niche signals. PAPERCLIP:
Volume 31(4)
Pages 474-86
Published 2014-11-24
DOI 10.1016/j.devcel.2014.10.004
PII S1534-5807(14)00628-5
PMID 25453558
PMC PMC4254588
MeSH Aging Animals Cell Differentiation / physiology Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Gene Expression Regulation, Developmental / physiology Janus Kinases / metabolism* Male Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* STAT Transcription Factors / metabolism* Sex Determination Processes / physiology* Signal Transduction / physiology Stem Cell Niche / physiology Stem Cells / cytology* Testis / metabolism* Transcription Factors / metabolism
IF 10.092
Times Cited 21
Drosophila tj-Gal4