RRC ID 32534
著者 Hattori Y, Usui T, Satoh D, Moriyama S, Shimono K, Itoh T, Shirahige K, Uemura T.
タイトル Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.
ジャーナル Dev Cell
Abstract The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than class IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits.
巻・号 27(5)
ページ 530-44
公開日 2013-12-9
DOI 10.1016/j.devcel.2013.10.024
PII S1534-5807(13)00641-2
PMID 24290980
MeSH Animals Chromatin / genetics Dendrites / physiology Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / cytology Drosophila melanogaster / growth & development Drosophila melanogaster / physiology* Gene Expression Regulation, Developmental Genome-Wide Association Study Larva / cytology Larva / physiology Morphogenesis / genetics* Nuclear Proteins / genetics* Nuclear Proteins / metabolism Sensory Receptor Cells / physiology* Sensory Receptor Cells / ultrastructure Tenascin / genetics Tenascin / metabolism Transcription Factors / genetics* Transcription Factors / metabolism Transcription, Genetic / physiology* Transcriptome
IF 10.092
引用数 32
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ NP6658-GAL4 (Ten-m-GAL4 DGRC#114023)