論文 - 詳細
| RRC ID | 32534 |
|---|---|
| 著者 | Hattori Y, Usui T, Satoh D, Moriyama S, Shimono K, Itoh T, Shirahige K, Uemura T. |
| タイトル | Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier. |
| ジャーナル | Dev Cell |
| Abstract |
The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than class IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits. |
| 巻・号 | 27(5) |
| ページ | 530-44 |
| 公開日 | 2013-12-9 |
| DOI | 10.1016/j.devcel.2013.10.024 |
| PII | S1534-5807(13)00641-2 |
| PMID | 24290980 |
| MeSH | Animals Chromatin / genetics Dendrites / physiology Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / cytology Drosophila melanogaster / growth & development Drosophila melanogaster / physiology* Gene Expression Regulation, Developmental Genome-Wide Association Study Larva / cytology Larva / physiology Morphogenesis / genetics* Nuclear Proteins / genetics* Nuclear Proteins / metabolism Sensory Receptor Cells / physiology* Sensory Receptor Cells / ultrastructure Tenascin / genetics Tenascin / metabolism Transcription Factors / genetics* Transcription Factors / metabolism Transcription, Genetic / physiology* Transcriptome |
| IF | 10.092 |
| 引用数 | 32 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | NP6658-GAL4 (Ten-m-GAL4 DGRC#114023) |