RRC ID |
32534
|
著者 |
Hattori Y, Usui T, Satoh D, Moriyama S, Shimono K, Itoh T, Shirahige K, Uemura T.
|
タイトル |
Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.
|
ジャーナル |
Dev Cell
|
Abstract |
The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than class IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits.
|
巻・号 |
27(5)
|
ページ |
530-44
|
公開日 |
2013-12-9
|
DOI |
10.1016/j.devcel.2013.10.024
|
PII |
S1534-5807(13)00641-2
|
PMID |
24290980
|
MeSH |
Animals
Chromatin / genetics
Dendrites / physiology
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Drosophila melanogaster / cytology
Drosophila melanogaster / growth & development
Drosophila melanogaster / physiology*
Gene Expression Regulation, Developmental
Genome-Wide Association Study
Larva / cytology
Larva / physiology
Morphogenesis / genetics*
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Sensory Receptor Cells / physiology*
Sensory Receptor Cells / ultrastructure
Tenascin / genetics
Tenascin / metabolism
Transcription Factors / genetics*
Transcription Factors / metabolism
Transcription, Genetic / physiology*
Transcriptome
|
IF |
10.092
|
引用数 |
32
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ショウジョウバエ |
NP6658-GAL4 (Ten-m-GAL4
DGRC#114023) |