RRC ID 32854
Author Miyamoto K, Adachi Y, Osada T, Watanabe T, Kimura HM, Setsuie R, Miyashita Y.
Title Dissociable memory traces within the macaque medial temporal lobe predict subsequent recognition performance.
Journal J. Neurosci.
Abstract Functional magnetic resonance imaging (fMRI) studies have revealed that activity in the medial temporal lobe (MTL) predicts subsequent memory performance in humans. Because of limited knowledge on cytoarchitecture and axonal projections of the human MTL, precise localization and characterization of the areas that can predict subsequent memory performance are benefited by the use of nonhuman primates in which integrated approach of the MRI- and cytoarchiture-based boundary delineation is available. However, neural correlates of this subsequent memory effect have not yet been identified in monkeys. Here, we used fMRI to examine activity in the MTL during memory encoding of events that monkeys later remembered or forgot. Application of both multivoxel pattern analysis and conventional univariate analysis to high-resolution fMRI data allowed us to identify memory traces within the caudal entorhinal cortex (cERC) and perirhinal cortex (PRC), as well as within the hippocampus proper. Furthermore, activity in the cERC and the hippocampus, which are directly connected, was responsible for encoding the initial items of sequentially presented pictures, which may reflect recollection-like recognition, whereas activity in the PRC was not. These results suggest that two qualitatively distinct encoding processes work in the monkey MTL and that recollection-based memory is formed by the interplay of the hippocampus with the cERC, a focal cortical area anatomically closer to the hippocampus and hierarchically higher than previously believed. These findings will advance the understanding of common memory system between humans and monkeys and accelerate fine electrophysiological characterization of these dissociable memory traces in the monkey MTL.
Volume 34(5)
Pages 1988-97
Published 2014-1-29
DOI 10.1523/JNEUROSCI.4048-13.2014
PII 34/5/1988
PMID 24478378
MeSH Analysis of Variance Animals Association Learning / physiology* Brain Mapping* Cues Female Functional Laterality Hippocampus / blood supply Hippocampus / physiology* Image Processing, Computer-Assisted Macaca fascicularis Magnetic Resonance Imaging Male Mental Recall / physiology* Neuropsychological Tests Oxygen / blood Pattern Recognition, Visual / physiology Photic Stimulation Recognition (Psychology) / physiology* Temporal Lobe / blood supply Temporal Lobe / physiology* Wakefulness
IF 6.074
Times Cited 9
Japanese macaques