論文 - 詳細
| RRC ID | 33018 |
|---|---|
| 著者 | Kondo S, Senoo-Matsuda N, Hiromi Y, Miura M. |
| タイトル | DRONC coordinates cell death and compensatory proliferation. |
| ジャーナル | Mol Cell Biol |
| Abstract |
Accidental cell death often leads to compensatory proliferation. In Drosophila imaginal discs, for example, gamma-irradiation induces extensive cell death, which is rapidly compensated by elevated proliferation. Excessive compensatory proliferation can be artificially induced by "undead cells" that are kept alive by inhibition of effector caspases in the presence of apoptotic stimuli. This suggests that compensatory proliferation is induced by dying cells as part of the apoptosis program. Here, we provide genetic evidence that the Drosophila initiator caspase DRONC governs both apoptosis execution and subsequent compensatory proliferation. We examined mutants of five Drosophila caspases and identified the initiator caspase DRONC and the effector caspase DRICE as crucial executioners of apoptosis. Artificial compensatory proliferation induced by coexpression of Reaper and p35 was completely suppressed in dronc mutants. Moreover, compensatory proliferation after gamma-irradiation was enhanced in drice mutants, in which DRONC is activated but the cells remain alive. These results show that the apoptotic pathway bifurcates at DRONC and that DRONC coordinates the execution of cell death and compensatory proliferation. |
| 巻・号 | 26(19) |
| ページ | 7258-68 |
| 公開日 | 2006-10-1 |
| DOI | 10.1128/MCB.00183-06 |
| PII | 26/19/7258 |
| PMID | 16980627 |
| PMC | PMC1592896 |
| MeSH | Animals Apoptosis / radiation effects Caspases / metabolism* Cell Death / physiology Cell Proliferation Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Embryo, Nonmammalian / cytology Eye / cytology Eye / pathology Gamma Rays Genome, Insect / genetics Models, Biological Mutant Proteins / metabolism Mutation / genetics Phenotype |
| IF | 3.611 |
| 引用数 | 131 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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