RRC ID 33018
Author Kondo S, Senoo-Matsuda N, Hiromi Y, Miura M.
Title DRONC coordinates cell death and compensatory proliferation.
Journal Mol. Cell. Biol.
Abstract Accidental cell death often leads to compensatory proliferation. In Drosophila imaginal discs, for example, gamma-irradiation induces extensive cell death, which is rapidly compensated by elevated proliferation. Excessive compensatory proliferation can be artificially induced by "undead cells" that are kept alive by inhibition of effector caspases in the presence of apoptotic stimuli. This suggests that compensatory proliferation is induced by dying cells as part of the apoptosis program. Here, we provide genetic evidence that the Drosophila initiator caspase DRONC governs both apoptosis execution and subsequent compensatory proliferation. We examined mutants of five Drosophila caspases and identified the initiator caspase DRONC and the effector caspase DRICE as crucial executioners of apoptosis. Artificial compensatory proliferation induced by coexpression of Reaper and p35 was completely suppressed in dronc mutants. Moreover, compensatory proliferation after gamma-irradiation was enhanced in drice mutants, in which DRONC is activated but the cells remain alive. These results show that the apoptotic pathway bifurcates at DRONC and that DRONC coordinates the execution of cell death and compensatory proliferation.
Volume 26(19)
Pages 7258-68
Published 2006-10
DOI 10.1128/MCB.00183-06
PII 26/19/7258
PMID 16980627
PMC PMC1592896
MeSH Animals Apoptosis / radiation effects Caspases / metabolism* Cell Death / physiology Cell Proliferation Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Embryo, Nonmammalian / cytology Eye / cytology Eye / pathology Gamma Rays Genome, Insect / genetics Models, Biological Mutant Proteins / metabolism Mutation / genetics Phenotype
IF 3.813
Times Cited 105
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
Drosophila