Reference - Detail
| RRC ID | 33039 |
|---|---|
| Author | Brunet T, Bouclet A, Ahmadi P, Mitrossilis D, Driquez B, Brunet AC, Henry L, Serman F, Béalle G, Ménager C, Dumas-Bouchiat F, Givord D, Yanicostas C, Le-Roy D, Dempsey NM, Plessis A, Farge E. |
| Title | Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria. |
| Journal | Nat Commun |
| Abstract |
The modulation of developmental biochemical pathways by mechanical cues is an emerging feature of animal development, but its evolutionary origins have not been explored. Here we show that a common mechanosensitive pathway involving β-catenin specifies early mesodermal identity at gastrulation in zebrafish and Drosophila. Mechanical strains developed by zebrafish epiboly and Drosophila mesoderm invagination trigger the phosphorylation of β-catenin-tyrosine-667. This leads to the release of β-catenin into the cytoplasm and nucleus, where it triggers and maintains, respectively, the expression of zebrafish brachyury orthologue notail and of Drosophila Twist, both crucial transcription factors for early mesoderm identity. The role of the β-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila. This suggests mesoderm mechanical induction dating back to at least the last bilaterian common ancestor more than 570 million years ago, the period during which mesoderm is thought to have emerged. |
| Volume | 4 |
| Pages | 2821 |
| Published | 2013-11-27 |
| DOI | 10.1038/ncomms3821 |
| PII | ncomms3821 |
| PMID | 24281726 |
| PMC | PMC3868206 |
| MeSH | Animals Armadillo Domain Proteins / metabolism* Biological Evolution* Conserved Sequence / physiology Drosophila Drosophila Proteins / metabolism* Female Fetal Proteins Male Mechanotransduction, Cellular* / physiology Mesoderm / physiology* Signal Transduction / physiology T-Box Domain Proteins / metabolism Transcription Factors / metabolism* Twist-Related Protein 1 / metabolism Zebrafish Zebrafish Proteins / metabolism* beta Catenin / metabolism* |
| IF | 12.121 |
| Times Cited | 87 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 25 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 7873R-2 |