論文 - 詳細
| RRC ID | 33040 |
|---|---|
| 著者 | Degoutin JL, Milton CC, Yu E, Tipping M, Bosveld F, Yang L, Bellaiche Y, Veraksa A, Harvey KF. |
| タイトル | Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. |
| ジャーナル | Nat Cell Biol |
| Abstract |
The atypical cadherins Fat (Ft) and Dachsous (Ds) control tissue growth through the Salvador-Warts-Hippo (SWH) pathway, and also regulate planar cell polarity and morphogenesis. Ft and Ds engage in reciprocal signalling as both proteins can serve as receptor and ligand for each other. The intracellular domains (ICDs) of Ft and Ds regulate the activity of the key SWH pathway transcriptional co-activator protein Yorkie (Yki). Signalling from the FtICD is well characterized and controls tissue growth by regulating the abundance of the Yki-repressive kinase Warts (Wts). Here we identify two regulators of the Drosophila melanogaster SWH pathway that function downstream of the DsICD: the WD40 repeat protein Riquiqui (Riq) and the DYRK-family kinase Minibrain (Mnb). Ds physically interacts with Riq, which binds to both Mnb and Wts. Riq and Mnb promote Yki-dependent tissue growth by stimulating phosphorylation-dependent inhibition of Wts. Thus, we describe a previously unknown branch of the SWH pathway that controls tissue growth downstream of Ds. |
| 巻・号 | 15(10) |
| ページ | 1176-85 |
| 公開日 | 2013-10-1 |
| DOI | 10.1038/ncb2829 |
| PII | ncb2829 |
| PMID | 23955303 |
| PMC | PMC4157670 |
| MeSH | Animals Cadherins / genetics* Cadherins / metabolism* Cells, Cultured Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism* Female Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism* Male Phosphorylation Protein Binding Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Signal Transduction* |
| IF | 20.042 |
| 引用数 | 38 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |