RRC ID 33050
著者 Tang H, Kambris Z, Lemaitre B, Hashimoto C.
タイトル A serpin that regulates immune melanization in the respiratory system of Drosophila.
ジャーナル Dev Cell
Abstract Epithelial tissues facing the external environment are essential to combating microbial infection. In addition to providing a physical barrier, epithelial tissues mount chemical defenses to prevent invasion of internal tissues by pathogens. Here, we describe that the melanization reaction implicated in host defense is activated in the respiratory system, the trachea, of Drosophila. Tracheal melanization can be activated by the presence of microorganisms but is normally blocked by Spn77Ba, a protease inhibitor in the serpin family. Spn77Ba inhibits a protease cascade involving the MP1 and MP2 proteases that activates phenol oxidase, a key enzyme in melanin biosynthesis. Unexpectedly, we found that tracheal melanization resulting from Spn77Ba disruption induces systemic expression of the antifungal peptide Drosomycin via the Toll pathway. Such signaling between local and systemic immune responses could represent an alarm mechanism that prepares the host in case a pathogen breaches epithelial defenses to invade internal tissues.
巻・号 15(4)
ページ 617-26
公開日 2008-10-1
DOI 10.1016/j.devcel.2008.08.017
PII S1534-5807(08)00341-9
PMID 18854145
PMC PMC2671232
MeSH Animals Antifungal Agents / metabolism Drosophila / genetics Drosophila / metabolism Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism Melanins / immunology* Melanins / metabolism* Models, Immunological Monophenol Monooxygenase / antagonists & inhibitors Mutation Serpins / genetics Serpins / metabolism Serpins / physiology* Trachea / cytology Trachea / metabolism*
IF 10.092
引用数 88
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ UAS-Spn77Ba-IR