RRC ID 33280
著者 Irving AA, Yoshimi K, Hart ML, Parker T, Clipson L, Ford MR, Kuramoto T, Dove WF, Amos-Landgraf JM.
タイトル The utility of Apc-mutant rats in modeling human colon cancer.
ジャーナル Dis Model Mech
Abstract Prior to the advent of genetic engineering in the mouse, the rat was the model of choice for investigating the etiology of cancer. Now, recent advances in the manipulation of the rat genome, combined with a growing recognition of the physiological differences between mice and rats, have reignited interest in the rat as a model of human cancer. Two recently developed rat models, the polyposis in the rat colon (Pirc) and Kyoto Apc Delta (KAD) strains, each carry mutations in the intestinal-cancer-associated adenomatous polyposis coli (Apc) gene. In contrast to mouse models carrying Apc mutations, in which cancers develop mainly in the small intestine rather than in the colon and there is no gender bias, these rat models exhibit colonic predisposition and gender-specific susceptibility, as seen in human colon cancer. The rat also provides other experimental resources as a model organism that are not provided by the mouse: the structure of its chromosomes facilitates the analysis of genomic events, the size of its colon permits longitudinal analysis of tumor growth, and the size of biological samples from the animal facilitates multiplexed molecular analyses of the tumor and its host. Thus, the underlying biology and experimental resources of these rat models provide important avenues for investigation. We anticipate that advances in disease modeling in the rat will synergize with resources that are being developed in the mouse to provide a deeper understanding of human colon cancer.
巻・号 7(11)
ページ 1215-25
公開日 2014-11-1
DOI 10.1242/dmm.016980
PII dmm.016980
PMID 25288683
PMC PMC4213726
MeSH Animals Colonic Neoplasms / etiology Colonic Neoplasms / genetics* Colonic Neoplasms / pathology Disease Models, Animal* Early Diagnosis Genotype Humans Mutation* Phenotype Rats
IF 4.651
引用数 28
WOS 分野 PATHOLOGY CELL BIOLOGY
リソース情報
ラット F344-Apcm1Kyo(strainID=714)