Reference - Detail
| RRC ID | 33363 |
|---|---|
| Author | Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA. |
| Title | sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. |
| Journal | Cell |
| Abstract |
Antagonists of several growth factor signaling pathways play important roles in developmental patterning by limiting the range of the cognate inducer. Here, we describe an antagonist of FGF signaling that patterns apical branching of the Drosophila airways. In wild-type embryos, the Branchless FGF induces secondary branching by activating the Breathless FGF receptor near the tips of growing primary branches. In sprouty mutants, the FGF pathway is overactive and ectopic branches are induced on the stalks of primary branches. We show that FGF signaling induces sprouty expression in the nearby tip cells, and sprouty acts nonautonomously and in a competitive fashion to block signaling to the more distant stalk cells. sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development. |
| Volume | 92(2) |
| Pages | 253-63 |
| Published | 1998-1-23 |
| DOI | 10.1016/s0092-8674(00)80919-8 |
| PII | S0092-8674(00)80919-8 |
| PMID | 9458049 |
| MeSH | Amino Acid Sequence Animals Base Sequence Body Patterning / genetics* Cell Membrane / chemistry DNA, Complementary / genetics Drosophila / embryology* Drosophila / genetics Drosophila Proteins* Fibroblast Growth Factors / physiology* Gene Expression Regulation, Developmental Insect Proteins / analysis Insect Proteins / chemistry Insect Proteins / genetics* Membrane Proteins* Molecular Sequence Data Mutation Phenotype Restriction Mapping Sequence Analysis, DNA Signal Transduction / physiology* Trachea / embryology |
| IF | 38.637 |
| Times Cited | 600 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 21 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |