論文 - 詳細
| RRC ID | 33621 |
|---|---|
| 著者 | Jetti SK, Vendrell-Llopis N, Yaksi E. |
| タイトル | Spontaneous activity governs olfactory representations in spatially organized habenular microcircuits. |
| ジャーナル | Curr Biol |
| Abstract |
The medial habenula relays information from the sensory areas via the interpeduncular nucleus to the periaqueductal gray that regulates animal behavior under stress conditions. Ablation of the dorsal habenula (dHb) in zebrafish, which is equivalent to the mammalian medial habenula, was shown to perturb experience-dependent fear. Therefore, understanding dHb function is important for understanding the neural basis of fear. In zebrafish, the dHb receives inputs from the mitral cells (MCs) of the olfactory bulb (OB), and odors can trigger distinct behaviors (e.g., feeding, courtship, alarm). However, it is unclear how the dHb processes olfactory information and how these computations relate to behavior. In this study, we demonstrate that the odor responses in the dHb are asymmetric and spatially organized despite the unorganized OB inputs. Moreover, we show that the spontaneous dHb activity is not random but structured into functionally and spatially organized clusters of neurons, which reflects the favored states of the dHb network. These dHb clusters are also preserved during odor stimulation and govern olfactory responses. Finally, we show that functional dHb clusters overlap with genetically defined dHb neurons, which regulate experience-dependent fear. Thus, we propose that the dHb is composed of functionally, spatially, and genetically distinct microcircuits that regulate different behavioral programs. |
| 巻・号 | 24(4) |
| ページ | 434-9 |
| 公開日 | 2014-2-17 |
| DOI | 10.1016/j.cub.2014.01.015 |
| PII | S0960-9822(14)00016-5 |
| PMID | 24508164 |
| MeSH | Aging Animals Behavior, Animal Habenula / physiology* Olfactory Bulb / physiology* Smell / physiology Zebrafish |
| IF | 9.601 |
| 引用数 | 42 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(lhx2a:Gap43-YFP) |